Recent publications published by researchers at the MRC WIMM.
SFX-01 is therapeutic against myeloproliferative disorders caused by activating mutations in Shp2.
Cho H-J. et al, (2025), EMBO Mol Med
Detecting and quantifying clonal selection in somatic stem cells.
Körber V. et al, (2025), Nat Genet
PROM1/CD133 MARKS A PROLIFERATIVE STEM CELL LIKE POPULATION OF BLASTS IN KMT2A REARRANGED INFANT ALL.
Cross JW. et al, (2025), Blood Adv
Plants monitor the integrity of their barrier by sensing gas diffusion.
Iida H. et al, (2025), Nature
Visible traits demonstrate that crispant founder mice can be used for phenotypic assessment
Tillotson R. et al, (2025)
Early NK-cell and T-cell dysfunction marks progression to severe dengue in patients with obesity and healthy weight.
Gregorova M. et al, (2025), Nat Commun, 16
The spatiotemporal distribution of human pathogens in ancient Eurasia.
Sikora M. et al, (2025), Nature
Silencing of SOD1 sensitises ATRX-deficient cells to camptothecin treatment through increased activity of the Alternative Lengthening of Telomeres pathway
ROSE A. et al, (2025), Human Molecular Genetics
Clinical significance of preleukemic somatic GATA1 mutations in children with Down syndrome.
Elliott N. et al, (2025), Blood
Iron deficiency causes aspartate-sensitive dysfunction in CD8+ T cells.
Teh MR. et al, (2025), Nat Commun, 16
Engineering antisense oligonucleotides for targeted mRNA degradation through lysosomal trafficking.
Kashyap D. et al, (2025), Chem Sci
REnformer, a single-cell ATAC-seq predicting model to investigate open chromatin sites
Riva SG. et al, (2025)
Genome-Wide Association Studies of Down Syndrome Associated Congenital Heart Defects Suggests a Genetically Heterogeneous Risk for CHD in DS.
Feldman ER. et al, (2025), Genet Epidemiol, 49
Measure selection for an electronic patient-reported outcome (ePRO) system for CAR T-cell therapy patients: a modified Delphi consensus study
Hughes SE. et al, (2025), Eclinicalmedicine, 84
Validation of the "Patient-Acceptable Symptom State" Question as Outcome Measure in AChR Myasthenia Gravis: A Multicentre, Prospective Study.
Spagni G. et al, (2025), Eur J Neurol, 32